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The full MK 677 guide: Benefits, dosages and side effects

The MK 677 guide

MK 677, also known as Ibutamoren, has gained popularity among bodybuilders and athletes due to its effect on growth hormone levels and IGF-1.

In this guide, we will provide answers to many common questions about Ibutamoren.

What is MK 677?

MK 677 is a Growth-Hormone-Releasing-Hormone, or a Growth Hormone secretagogue. As the name implies, this means it causes a release in Growth Hormone.

It does this by mimicking the hormone ghrelin in the brain. You may have heard about this hormone before as it is a key chemical in hunger. 

Recently, there have been a few of these products to surface on the market, including Growth-Hormone-Releasing-Peptide-6 and Hexarelin. 

One of the benefits of MK-677, compared to other growth hormone releasing substances, is that it doesn’t affect cortisol levels.

This is a huge advantage, because cortisol increases fat storage, anxiety and blood pressure. Ibutamoren does not have any of these unwanted effects.

Mk 677 Ibutamoren molecule

What are the benefits of MK-677?

The benefits of MK-677 include muscle-building, a reduction in muscle wasting, better bone density, improved sleep, and anti-aging properties. It may also have nootropic effects and it can be beneficial in treating growth hormone deficiencies. Read on for a more in-depth look at these benefits. 

Helps build muscle

Ibutamoren is frequently used as an anabolic substance to increase lean body mass. It is orally active and can be taken once a day. MK-677 stimulates Growth Hormone and IGF-1 which each factor in significantly maintaining lean body mass. 

Growth hormone stimulates muscle size and strength, and Ibutamoren has proven to effectively stimulate the secretion of GH.

Reduces muscle wasting

MK-677 has shown in recent studies to alleviate muscle wasting, which can be caused by a decline in protein within an individual’s diet. In one study a group of healthy young adults were tested to determine if MK-677 could reverse protein catabolism and the results proved to be quite positive. As a result, MK-677 is theorized to be possibly being an effective treatment for individuals who suffer from catabolic conditions.

Improves sleep

By increasing Growth Hormone, Ibutamoren can help improve sleep quality. We know from studies that it improves sleep quality and the duration of REM (Rapid Eye Movement) sleep duration.

Apart from scientific studies, there have been many reports of subjective improvements in sleep quality.

This is beneficial for multiple reasons, one of which is better recovery after working out.

MK-677 (Ibutamoren) liquid 30ml (25mg per ml) - HQSARMS
MK-677 (Ibutamoren)

MK-677 side effects

When to take Ibutamoren?

You should take MK-677 in a single dose each day at the same time, preferably in the evening before bedtime. If you want to take advantage of the increased appetite because you are bulking, then taking it in the morning is a good option.

How long to take MK 677?

The minimum recommended cycle length for MK 677 is 8 weeks, but 16 to 20 weeks is actually better. While the increase in growth hormone levels is pretty much instant, IGF-1 levels take a while to build up. This basically means that the longer you take Ibutamoren, the more effective it is.

During clinical trials the participants where given 25 mg daily for a period of 2 years.

How long does it take to work?

You will notice a strong increase in appetite already during the first week. Some people would describe it as extremely hungry. During the second week, you should notice the improved sleep quality associated with Ibutamoren. The anabolic effects of MK-677 will take longer to kick in. It takes at least 4 weeks to notice any difference in muscle mass or strength and these benefits will become more apparent when taken for an extended amount of time.

What is the optimal dosage of MK-677?

Ibutamoren is used in dosages between 10 and 50 mg per day. The optimal dose of MK-677 is roughly 25 mg per day. Anything above this dose will likely produce more side effects, while having limited additional benefits.

How does Ibutamoren work?

Is MK 677 a SARM?

Some people mistake MK677 for a SARM (Selective Androgen Receptor Modulator). In reality, it’s actually not a SARM, but a growth hormone secretagogue. Unlike SARMs, which target the androgen receptors much in the same way as anabolic steroids, Ibutamoren influences the levels of human growth hormone and IGF-1.

Does MK 677 cause testosterone suppression?

Since Ibutamoren doesn’t affect the androgen receptors, it does not lead to a decrease in natural testosterone production. Since it is not suppressive, there is no need for any type of PCT.

The legal status of this compound is the same as other SARMs. So yes, MK 677 is legal to buy and use in every country around the world. There is one exception, Australia, where you will need a doctor’s prescription for it because it’s a Schedule 4 prescription only compound.

Ibutamoren has not been approved for human consumption, and is currently still a investigational new drug. This means it can be legally sold as a research chemical.

For more information on the legal status of SARMs, read our blog post: Are SARMs legal in Europe?

Can I stack MK-677?

Ibutamoren can be stacked with SARMs or other compounds, depending on your goal. It can be used for cutting purposes, in combination with Cardarine, or for bulking in a stack with LGD-4033 or RAD-140.

For more information about stacking SARMs, read our blog post: Stacking SARMs: The ultimate guide.

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