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The complete guide to Cardarine: Dosage, benefits and usage

GW-501516 Cardarine

What is Cardarine? Does it have any side effects? What results can you expect from using this product? We will cover the answer to these and other questions in this article.

What is Cardarine?

Cardarine, also known as GW-501516 or Endurobol, is developed in the 1990s by two pharmaceutical corporations: GlaxoSmithKline and Ligand Pharmaceuticals. Its main goal is to prevent diseases related to heart disease and metabolic syndrome. Thanks to its incredible ability to accelerate metabolism and burn fat tissue, it quickly gained popularity among athletes. 

Due to its selective action, GW-501516 is often mistakenly classified as a SARM (Selective Androgen Receptor Modulators). This is incorrect, because it doesn’t bind to the androgen receptors like SARMs do. Instead, it is a PPAR-delta receptor agonist. 

The best SARM for weight loss

Cardarine is widely considered to be the best SARM for weight loss. But in reality, it actually isn’t a SARM but a so-called PPAR delta agonist. It increases the uptake of glucose, and encourages the body to burn fatty acids rather than carbohydrates.

How does Cardarine work?

Cardarine works by binding to and activating PPAR-delta in your cells (primarily in your muscles), and by stimulating the genes responsible for energy use.

As a result, it is able to increase energy levels, burn more fat, and enhance endurance, meanwhile lowering blood lipid levels.

Cardarine benefits

There are many possible benefits associated with the use of Cardarine. Research has shown that this compound is able to increase endurance and stamina, accelerate fat burning, and improve recovery after training.

Accelerates fat burning

For many people the most crucial feature of Cardarine is that it accelerates fat burning. The action of GW-501516, however, differs significantly from an average cutting supplement, which usually contains only thermogenic substances.  By acting on the pathway PPAR-delta, it activates a large number of genes responsible for fat burning. It also changes the way our body reacts to meals that have a high glycemic index.

Increases strength and endurance

Increased strength is associated with the activation of the PPARδ path. It changes the way our body metabolises fats and glucose, thus ensuring greater endurance. The opinion of GW-501516 users and clinical trials confirm this. In one of these studies, mice were subjected to severe endurance training.After using Cardarine, they were able to cover a much longer distance than in the control study and showed increased tolerance to chronic exercise.

In another study done on humans, the participants experienced a significant increase in strength. However, at this stage, we cannot say whether this is due to the anabolic properties of the substance or solely to more efficient energy management by the body. The fact that GW-501516 is on the WADA list (this means that professionals can not use it) gives a picture of how strong this substance is. 

Helps to fight obesity

In another study, 6 obese people received Cardarine in a double-blind, random and controlled trial. It helped to cure the symptoms of metabolic syndrome in all subjects without causing any side effects.
The participants took a maximum of 10 mg per day for only two weeks. After such a short period of time, positive changes in liver steatosis, insulin sensitivity and lipid levels were already visible. Therefore, we can conclude that GW-501516 is a great supplement to fight insulin resistance caused by obesity and chronic inflammation.
In yet another study, conducted this time on obese mice, Cardarine reduced the risk of heart disease by lowering LDL cholesterol, triglycerides and insulin levels. It also reduced the overproduction of glucose by the liver. This means that Endurobol can be a good supplement for people with type 2 diabetes (if it has the same effect in humans).

Potential Cardarine side effects

There are not many studies on Cardarine side effects, especially on humans. Users also very rarely complain about any side effects. However, we have found studies that indicate that this substance may also potentially have side effects. 

Firstly, as mentioned earlier, GW-501516 has the ability to destroy degenerated liver cells. While this is usually a positive thing, it is definitely harmful for people with liver disease. In such people, whose liver has problems with proper work without additional means, Endurobol, by destroying some cells, aggravates these problems. This is why GSK has discontinued its marketing of the drug. 

The other potential side effect is also related to the benefit mentioned above. Due to the acceleration of the expansion of some cells, the risk of their mutation is also increasing, thus increasing the risk of cancer.

Please note that the above-mentioned side effects were observed during the studies on mice. None of these side effects has been observed in human clinical trials – however, these studies were too short for such effects to be observed. 

Cardarine dosage

During clinical trials, the administered doses ranged from 2.5mg to 10mg per day. 

Athletes usually take 10mg to 20mg daily for 6-12 weeks, with 20 mg as most common dosage. If you decide on a dose of 20 mg, you should divide it into two servings – 10 mg in the morning and 10 mg in the evening, as the half-life of GW-501516 is about 16 hours.

Stacking Cardarine

GW-501516 can be used stand-alone, but it is commonly stacked with SARMs in order to maximize effectiveness. One very popular stack for cutting is Cardarine and Ostarine (MK-2866).

WeekCardarine dosageOstarine dosage
120 mg per day20 mg per day
220 mg per day20 mg per day
320 mg per day20 mg per day
420 mg per day20 mg per day
520 mg per day20 mg per day
620 mg per day20 mg per day
720 mg per day20 mg per day
820 mg per day20 mg per day

Best GW-501516 cycles

When your goal is simply to increase endurance, 20 mg of Cardarine is enough. But if you want to use it as a cutting cycle, the effects can be greatly enhanced when you combine it with Ostarine.

How to take Cardarine?

Since the half-life is relatively short, it is best to divide the daily dose in half. One dose should be taken in the morning before the first meal and the other in the afternoon. If you decide to take GW once a day, it is best to do this on an empty stomach – this ensures the best absorption. 

Does Cardarine require a PCT?

GW-501516 does not target the androgen receptors like SARMs. This means that it doesn’t suppress testosterone production, and as a result there is no need for a PCT after a cycle of Cardarine.

Is Cardarine legal?

Cardarine (GW-501516) is legal in almost every country around the world, except for Australia. That is, as long as it is sold for research purposes. Because it is not approved for human consumption by the FDA, it can not be legally sold as a supplement in many countries. On top of that, it is considered doping by all professional sport associations.

Is Cardarine suppressive?

Cardarine doesn’t affect hormone levels at all, which means that it is not suppressive. It does not target the androgen receptors in the way that SARMs (and steroids) do. As a result, it has no effect on the natural production of testosterone.