What is MK-677?
MK-677, also known as Ibutamoren, is a growth hormone secretagogue that is highly popular among athletes and bodybuilders. It is one of those compounds that is often referred to as a SARM. But it actually isn’t a Selective Androgen Receptor Modulator at all.
Ibutamoren is actually a selective agonist of the growth hormone secretagogue. It mimics the action of ghrelin (the hormone that regulates appetite and the distribution and rate of use of energy) in the stomach, raising growth hormone and IGF-1 levels, but does not affect cortisol levels. It is the only orally active compound that stimulates the secretion of growth hormone (GH) and insulin-like growth factor 1 (IGF-1).
Other growth hormone secretagogues are mostly peptides, such as GHRP-2, GHRP-6, Hexarelin, and others. Most of these substances increase cortisol levels. The same is not true for MK 677, which is one of the reasons that make this a unique compound.
How does MK 677 work?
Human studies have shown MK 677, also known as Ibutamoren and Nutrobal to increase both muscle mass and bone mineral density. Dosed at 25mg daily, Ibutamoren increases IGF-1 levels by 60% in 6 weeks in humans. A 72% increase in IGF-1 levels was seen after 12 months.
Ibutamoren is frequently used as an anabolic substance, to increase lean body mass. It works by mimicking the ghrelin receptor, which is not something that many compounds are capable of.
MK 677 increases the secretion of Growth Hormone (GH) as well as Insulin-Like Growth factor (IGF-1). Both of these play a large role in muscle growth, recovery, and cell regeneration.
What are the benefits of MK 677?
MK 677 or Ibutamoren has a number of impressive health benefits, that go far beyond simply increasing muscle mass.
The main benefit of using MK 677 is that it raises both GH and IGF-1 levels in the body.
But, what does it mean to have increased levels of these hormones?
Well, both Growth hormone and Insulin-Like Growth Factor-1 assist in the growth of muscle mass, recovery, strength, and performance. Research also shows that MK677 can be beneficial in the treatment of catabolic conditions.
Reduces muscle wasting
MK 677 seems to reduce muscle wasting that can be caused by a decline in protein intake within a persons diet. One study on healthy, young individuals, focused on the possibility to reverse protein-induced catabolism. The result was positive. As a result, MK-677 is theorized to be possibly being an effective treatment for individuals who suffer from catabolic conditions.
Increase bone density
Several studies have indicated that long-term use of MK-677 can have tremendous results to increase bone mineral density. Bone loss is a very common problem in obese individuals, aging adults, and women with menopause. These distinct populations can have detrimental health problems due to low bone mineral density and MK-677 has proven to be an effective treatment for many of them.
In 24 healthy obese male volunteers, ibutamoren increased bone turnover.
Another study was performed on 187 elderly adults (65 years or older). Ibutamoren increased bone building, as measured by osteocalcin, a marker of bone turnover in multiple studies.
In one study with 292 post-menopausal women, ibutamoren increased bone mineral density, which helps increase bone strength and prevent osteoporosis.
Ibutamoren improves sleep quality
Growth hormone plays an important role in the quality of sleep. Because MK-677 Ibutamoren increases growth hormone, it improves sleep quality by prolonging the duration of REM sleep. This is the sleep stage where most recovery is taking place. This effect is shown in numerous scientific studies and in anecdotal evidence by many users.
Apart from scientific studies, there are many user reports that mention an improved sleep quality.
MK-677 for faster recovery
An increase in growth hormone levels has many positive effects. For instance, it provides faster recovery by improving tissue regeneration. This results in better healing of tendons as well as skin and nails.
Possible nootropic effects
Since MK-677 shares a lot of similar qualities to Ghrelin. We know that ghrelin has positive effects on cognitive functions. Because MK 677 binds to the same receptors as ghrelin, it is likely to have similair effects.
It is, however, important to point out that there have not been any scientific studies that prove this assumption. We do know about the vital role that REM sleep plays in cognitive functions. The role of IGF-1 on cognitive functions is also well-known.
Side effects of MK-677 Ibutamoren
Ibutamoren does not cause many side effects in most individuals. The most common side effects associated with the use of MK-677 include:
An increase in appetite
Ibutamoren mimics the effects of Ghrelin. As a result, MK-667 increases appetite significantly, just like ghrelin. This effect is strongest during the first couple of weeks.
Mild lower extremity edema
MK-677 can cause mild lower extremity edema, which basically means that it increases water retention in feet and hands. This effect is most apparent during the first few weeks.
Increase in insuline sensivity
Because Ibutamoren increases IGF-1 (Insulin-like growth factor 1), it can also increase blood sugar, which is a risk for people with diabetes or high insulin sensitivity.
Stacking Ibutamoren is a common practice among bodybuilders. Most users stack it with androgenic anabolic steroids or with SARMs, such as RAD-140 or LGD-4033. When combined with substances that target the androgen receptors, the anabolic effects of MK677 increase.
During clinical trials MK-677 was well tolerated by the subjects. No serious adverse effects where observed in any of the patients. There are no studies on the long-term side effects of MK-677.
No, MK 677 does not require a PCT because it doesn’t suppress testosterone levels.
Yes, Ibutamoren is completely legal. More info about the legal status of SARMs can be found in our article: Are SARMs legal in Europe?
No, Ibutamoren does not cause any suppression in testosterone levels because it doesn’t target androgen receptors. Studies confirm that MK-677 does not suppress testosterone levels.
The half-life of Ibutamoren is around 24 hours. Most users take it once per day.
The most common dose for Ibutamoren is 25mg per day. Using a higher dosage does not seem to be more effective.